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IL-6

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  • Product description
  • IL-6
    Interleukin-6
    REF: DS207711 96 tests 

    Intended use

    Immunoassay for the in vitro quantitative determination of IL-6 (interleukin-6) in human serum and plasma.

    Summary

    IL-6, a key mediator for inflammation and an early alarm signal of infection that becomes elevated as part of the inflammatory response, has emerged as a valuable biomarker in the management of sepsis.

    In a study of 1,032 patients with severe trauma, patients who subsequently developed septic complications had the highest IL-6 levels on day 1 following injury. Similarly, in a study of 50 patients following major surgery, IL-6 levels were correlated with the development of septic complications during the first 5 days following surgery (area under the curve [AUC] 0.82; 95% CI: 0.66 – 0.98), with a sensitivity of 90 % and selectivity of 58%. Furthermore, when IL-6 levels and clinical indicators were combined, sensitivity and selectivity increased to 100% and 79%, respectively. 

    Early peak IL-6 levels correlate significantly with the development of SIRS and sepsis. The degree of elevation in IL-6 levels can be used to differentiate SIRS from severe sepsis and septic shock, with higher IL-6 levels correlating with increased severity.

    As a marker for systemic inflammation, high IL-6 levels may be predictive of future organ dysfunction. In addition, continually elevated IL-6 levels have been reported 
    to be predictive of mortality in patients with sepsis.

    Reagents

    Materials provided
    • Coated Microplate, 8 x 12 strips, 96 wells, pre-coated with mouse monoclonal Anti-IL-6.
    • Calibrators, 6 vials, 1 mL each, ready to use; Concentrations: 0(A), 20(B), 50(C), 250(D), 1000(E) and 3000(F) pg/mL.
    • Enzyme Conjugate, 1 vial, 11 mL of HRP (horseradish peroxidase) labeled mouse monoclonal Anti-IL-6 in Tris-NaCl buffer containing BSA (bovine serum albumin). Contains 0.1% ProClin300 preservative.
    • Substrate, 1 vial, 11mL, ready to use, (tetramethylbenzidine) TMB.
    • Stop Solution, 1 vial, 6.0 ml of 1 mol/L sulfuric acid.
    • Wash Solution Concentrate, 1 vial, 25 mL (40X concentrated), PBS-Tween wash solution.
    • IFU, 1 copy.
    • Plate Lid: 1 piece.
    Materials required (but not provided)
    • Microplate reader with 450nm and 620nm wavelength absorbent capability.
    • Microplate washer. 
    • Incubator.
    • Plate shaker.
    • Micropipettes and multichannel micropipettes delivering 50μl with a precision of better than 1.5%.
    • Absorbent paper.
    • Distilled water

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